Introduction: Malaria is still one of the important parasitic diseases aroud the country and the major health problem in south – east of Iran.

 Methods: Based on the role of therapeutic effect and importance of failure rate of antimalaria drugs in national drug policy a joint study with collaboration of WHO on montoring of therapeutic efficacy of chloroqine has been done according to the latest WHO guideline in south & southeast provinces َin 2002-03.

 Results: According to the findings, from 144 uncomplicated cases who were eligible for 28 days follow up, only 21.5 % showed adequate clinical & parasitological response to chloroquine (ACPR), 17.4% showed early treatment failure ( ETF ) , 34.7% late clinical failure and 26.4% late parasitologcal failure (LPF).

 Conclusion: Based on the results, drug changing the first line antimalaria drug regimen is recommended for treatment of uncomplicated falciparum malaria.

 Hakim Research Journal 2006 8(4) 21-25.