Introduction: Male infertility constitutes the primary cause of infertility for up to 30% of couples amongst many other reasons. Genetic disorders are too important because DNA integrity in sperm is necessary for having healthy next generation. The aim of this study was to evaluate the baseline DNA damage in sperm samples obtained from normal and infertile individuals.
Methods: Baseline DNA damage in spermatozoa from fertile (n=30) and infertile (n=90) individuals was compared using a modified alkaline single cell gel electrophoresis (comet assay).This technique was used to assess DNA integrity in the cells by measuring damages reflected as strand break under alkaline conditions. The cells were embedded in agarose on glass slides followed by lysis of the cell membranes after which, damaged DNA strands migrate under electrophoresis from nucleus towards the anode and deposited to one side giving the appearance of a tail. DNA damage in each group was calculated following visual observation and grading of comets under a fluorescence microscope. The significance of inter-group differences was statistically evaluated using analysis of variance (ANOVA) and Post hoc tests.
Results: Results indicate that the average DNA damage in normal sample is less than any other groups. Samples from oligospermic, oligoasthenospermic and asthenospermic patients showed various degrees of DNA damage significantly different from normal (p<0.05). The highest degree of DNA damage was seen in asthenospermic samples.
Conclusion: DNA damage in infertile individuals is found to be higher than normal. The reason for this observation may be due to a deficiency in antioxidants which is essential present during spermatogenesis. The presence of antioxidants prevents DNA damages in sperms due to oxidative agents.
Hakim Research Journal 2005 8(2) 17- 2 4.
Introduction: Male external genitourinary anomalies are common and important. Eearly diagnosis and treatment of the diseases can prevent late organic and psycho– economic complications.
Methods: The most simple way of diagnosis is a thorough physical examination. In this study we examined 4260 young male students (6-12 yrs old) from 16 primary schools in Tehan. Then the parents of the children with anomaly were asked about their history of anomalies.
Results: Anomalies were found in 156 (3.6%) students. The common anomalies were inguinal hernia in 80 cases (51.3%), unilateral undescended testis in 35 (22.3%). Hypospadiasis in 13 (8.3%), bilateral undescended testes in 4 (2.56%) and epispadiasis as well as chordoe in 3 (1.9%), respectively . In previous operated cases, 102 (66%) had emergent operation, 24% had been diagnosed by their physicans and 10% with their parents by chance.
Conclusion: According to easy availability of this system and complications of delayed management, it is recommended that routine physical examinations must be done.
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Hakim Research Journal 2005 8(2) 13-16.
Asilian Bidgoli A (PhD), Ebrahimpour-Komleh H (PhD), Mousavirad SJ* (PhD)
Department of Computer Engineering, University of Kashan, Kashan, Iran
Original Article
Received: 23 Jan 2016, Accepted: 3 May 2016
Abstract
Introduction: Infertility is one of the most important problems, especially among males which has received special attention recently. Male infertility can be affected by different factors. There is now a large body of evidence to support the effects of life styles and environmental factors on semen quality. Data mining methods in artificial intelligence, as a decision support system, could be helpful in medical diagnosis of male infertility.
Methods: The influencing factors of seminal quality, and as a result ability to detect the infertility in males was assessed in this study using data mining algorithms in artificial intelligence. The dataset of 100 volunteers among students of University of Alicante were used. After data balancing different classifiers such as neural network were used to find the best classifier to predict the male infertility.
Results: The proposed algorithm is evaluated with different data mining algorithms to find a better analytical application of the algorithm. Support vector machine had the best accuracy (%95.15) to predict proposed infertility in male compared to the other classifiers. The proposed algorithm has a competitive accuracy compared to other algorithms.
Conclusion: The proposed algorithm is able to predict male infertility from lifestyle and environmental factors using data mining algorithms.
Key words: Male Infertility, Artificial intelligence, Data mining algorithms, Support vector machine, Support decision system
Please cite this article as follows:
Asilian Bidgoli A, Ebrahimpour-Komleh H, Mousavirad SJ. Male Infertility Prediction from Environmental Factors and Lifestyle Using Artificial Intelligence Algorithms. Hakim Health Sys Res 2016; 19(2): 72- 80.
*Corresponding Author: Department of Computer Engineering, University of Kashan, Kashan, Iran.
Tel: +98- 935- 4626334, E-mail: jalalmoosavirad@gmail.com
Please cite this article as follows: Alami A, Hosseini Z, Vahedian-Shahroodi M, Jafari A. Knowledge, attitude and practice of Iranian female high school students about iron supplementation: evaluation of Iron Supplementation National Program. Hakim Health Sys Res 2019; 22(1): 43- 51. |
Please cite this article as follows: Firouzbakht M, Tirgar A, Hajian- Tilaki K, Riahi M E, Bakouei F, Nikpour M. Social capital and single child in employed women. Hakim Health Sys Res. 2019; 22(3): 241-248. |
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